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Our Pipeline

Indication
discoveryIND enablingPhase 1Phase 2Phase 3
Multiple Myeloma &
Hematologic Cancers
Solid tumors
Autoimmune disease
Novel ADC Payload Platform

Our Indication Areas

  • QLi5 compounds overcome high blood partition issue shown in the 1st gen Proteasome Inhibitors
  • Higher therapeutic window achieved by efficacy vs. blood cell count change in MM (RPMI-8226) xenograft model
  • Good potential for other hematologic cancer indication with higher therapeutic window

1. Multiple Myeloma and Hematologic Cancers

  • QLi5 compounds show efficacy equal or superior to known proteasome inhibitors in animal models for multiple myeloma
  • Proven efficacy in animal models of haematological tumors different from multiple myeloma
  • Oral efficacy in animal models

2. Solid Tumors

  • QLi5 compounds show high efficacy in animal models for solid tumors
  • Accumulation in the tumor tissue
  • Oral efficacy in animal models

3. Auto-immune Diseases

  • QLi5 compounds show strong reduction of IgG secretion in ex-vivo experiments with plasma cells from patients with Systemic Lupus Erythematosus (SLE)

4. Novel ADC Payload Platform

Due to their extraordinary potency QLI5 compounds have been evaluated as payloads in ADCs

  • Cytotoxicity in pM range
  • Payload effective against non proliferating cells/independent from cell cycle
  • Improved Safety Profile
  • Ideal candidates for combination with I/O therapy
  • Door opener for ADC based Autoimmunity Intervention

About Us

Next Generation Proteasome inhibitors for unmet medical needs by an international Research & Development Network

Contact

  • QLi5 Therapeutics GmbH
    Otto-Hahn-Straße 15
    D – 44227 Dortmund
  • huber@QLi5tx.com
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